Carrier effect: Micro- and nanoplastics adsorb chemicals from their environment - phthalates, BPA, heavy metals, persistent organic pollutants - and can deliver them into tissue at the point of particle deposition. This potentially amplifies chemical exposure from multiple sources.
Inflammatory response: Cell and animal studies consistently show microplastic particles trigger inflammatory responses in gut tissue, lung tissue, and immune cells. Chronic inflammation is a recognized driver of cardiovascular disease, metabolic dysfunction, and cancer risk.
Oxidative stress: Nanoplastics generate reactive oxygen species in cell studies, damaging DNA and cellular structures through a recognized carcinogenic mechanism. Dose-response in humans is not yet characterized.
Gut microbiome disruption: Animal studies show microplastic ingestion alters gut microbiome composition, reduces microbial diversity, and increases intestinal permeability. Human relevance is under active investigation.
Tissue accumulation: Microplastics have been detected in human blood, placenta, breast milk, and lung tissue - confirming they cross biological barriers and accumulate in organs. Long-term consequences of this accumulation are unknown.