Cancer risk (Group 2A probable carcinogen): IARC classified acrylamide as probably carcinogenic to humans based on sufficient animal evidence and limited human evidence. The metabolite glycidamide is directly genotoxic, binding to DNA and causing mutations that can initiate tumor formation.
Kidney cancer: Meta-analyses have found statistically significant associations between dietary acrylamide and renal cell carcinoma. The kidney is a target organ in animal studies as well.
Endometrial and ovarian cancer: The Netherlands Cohort Study found positive dose-response relationships between dietary acrylamide and both endometrial and ovarian cancer in non-smoking women, considered the strongest epidemiological signal.
Neurotoxicity at high doses: Occupational acrylamide exposure causes peripheral neuropathy. Dietary levels are far below neurotoxic thresholds, but this confirms acrylamide's biological activity in humans.
Children's exposure: EFSA flagged children's higher per-body-weight exposure as a specific public health concern. Children's dietary patterns favor high-acrylamide foods, and their longer remaining lifetimes amplify cumulative risk.