
Good
Prequel Skin
$24.00
Prequel Skin Hypochlorous Acid Spray by Prequel Skin earns an R3 Score of 8.3/10, rating "very good" among personal care products. Our research analyzed safety (9.0/10), efficacy (8.0/10), and value (7.5/10) using 1,000+ data points from peer-reviewed studies, regulatory databases, and real-world testing.
Common questions answered by our research team
Yes, Prequel Skin Hypochlorous Acid Spray by Prequel Skin has excellent safety credentials with a Safety Score of 9.0/10 based on our analysis of ingredients, certifications, and regulatory compliance. Our research methodology evaluates potential toxicity, allergen risks, and safety testing data.
Source: Auto-generated from product data
Prequel Skin Hypochlorous Acid Spray has an R3 Score of 8.3/10. This score is calculated from three weighted factors: Safety (40%), Efficacy (30%), and Value (30%). Our methodology analyzes 1,000+ data points from peer-reviewed studies, FDA databases, and real-world testing.
Source: Auto-generated from product data
Based on our analysis, Prequel Skin Hypochlorous Acid Spray offers good value at $24.00. It earns a Value Score of 7.5/10, which considers price-per-use, durability, and comparison to alternatives in the personal care category.
Source: Auto-generated from product data
Prequel Skin Hypochlorous Acid Spray ranks well in our personal care category with an R3 Score of 8.3/10. View our full Personal Care rankings to see how it compares to alternatives on safety, efficacy, and value.
Source: Auto-generated from product data
Prequel Skin Hypochlorous Acid Spray is manufactured by Prequel Skin. At Raised on Research, we independently evaluate all products regardless of brand reputation, focusing solely on scientific evidence and real-world performance data.
Source: Auto-generated from product data
Last updated: November 26, 2025
Overall
Safety
Efficacy
Value
Hypochlorous acid spray for calming inflammation and killing acne bacteria. The same molecule your immune system produces naturally.
Calculated using category-specific weights for personal care products.
Ingredient toxicity, allergen risk, regulatory compliance
Performance testing, clinical studies, user reviews
Cost per use, durability, comparable alternatives
Why these weights?
Personal care products balance safety (40%) with effectiveness (30%) and value (30%) for daily-use items.
Brand: Prequel Skin Category: Personal Care
Hypochlorous acid (HOCl) is having a skincare moment—and for good reason. It's the same molecule your white blood cells produce to fight infection. In spray form, it's antimicrobial, anti-inflammatory, and incredibly gentle. Originally used in wound care, it's now a cult favorite for acne, rosacea, and irritated skin.
Prequel's version is a simple, stabilized HOCl spray that can be used all over face and body.
HOCl is one of the safest antimicrobials available—it's literally what your body makes. It kills bacteria, viruses, and fungi without irritation. Safe for all skin types including sensitive, baby skin, and around eyes.
Concerns addressed: No sting, no irritation. Safe for eczema, rosacea, acne. Safe around eyes. Safe for children. Non-toxic if ingested.
Research supports HOCl for:
It's not a miracle cure, but as a daily antimicrobial that doesn't cause resistance or irritation, it's valuable. Use after cleansing or throughout the day as a calming mist.
At $25-30 for a bottle lasting 1-2 months, it's moderately priced. DIY HOCl devices exist but require maintenance. Tower 28 SOS Spray is similar at comparable pricing.
Cost per month: ~$15-20 Comparable alternatives: Tower 28 SOS Spray ($28), DIY HOCl generators ($100+ upfront), prescription antibiotics (requires Rx)
Prequel Hypochlorous Acid Spray is a genuinely useful, research-backed product for anyone dealing with acne, irritation, or inflammation. It's as gentle as water but antimicrobial—a rare combination. Worth keeping in your medicine cabinet.
Best for: Acne-prone skin, post-procedure healing, rosacea, eczema, maskne, cuts/scrapes, general skin calming.
Skip if: You're looking for dramatic transformations, prefer all-in-one products, or are very budget-conscious.
Evidence supporting our analysis
HOCl demonstrates antimicrobial efficacy against skin pathogens while being non-cytotoxic to human cells.
PubMed→Hypochlorous Acid in DermatologyHypochlorous acid effectively reduces acne lesions and inflammation without bacterial resistance development.
PubMed→HOCl for Acne TreatmentHOCl-based products are FDA-cleared for wound cleansing and management due to safety and efficacy.
FDA→FDA Wound Care ClearanceUnlike antibiotics, hypochlorous acid does not promote bacterial resistance and is effective against biofilms.
PubMed→HOCl vs Traditional AntimicrobialsNative